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Scientific Challenges

Estimated incidence per 100,000 population (2008)
Source: World Health Organization

Confirmed multi-drug resistant TB cases (2008)
Source: World Health Organization

Estimated incidence (2007)
Source: World Health Organization

Estimated TB cases who are HIV-positive(2008)
Source: World Health Organization

TB
MDR-TB
HIV
HIV + TB

Using the tools of basic science, the KwaZulu-Natal Research Institute for Tuberculosis and HIV seeks new approaches to fighting these deadly diseases.

Scientific Developments

Outstanding Masters Students Wanted

Are you a high achieving student of the extraordinary with an honours degree in the Mathematical, Engineering or Biological sciences? Then we need to talk to you.

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Comment & Analysis

Did you know that Mtb scavenges iron from its host in order to intensify the infection. K-RITH post-doc Ryan Wells has taken another look at the mechanism the bacteria uses to extract iron from the host.

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Publications

Drug Resistant tuberculosis, KwaZulu-Natal, South Africa, 2001-2007. Emerg Infect Dis. 2011 Oct.

Environmental heme-based sensor proteins: Implications for understanding bacterial pathogenesis. Antioxid Redox Signal. 2012 Jun 13.

Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis. J Antimicrob Chemother. 2012 Feb.

In silico children and the glass mouse model Antimicrob Agents Chemother. 2011 Feb.

Mycobacterium tuberculosis WhiB3: a novel iron-sulfur cluster protein that regulates redox homeostasis and virulence. Antioxid Redox Signal. 2012 Apr 1.

Iron sulfur cluster proteins and microbial regulation. Curr Opin Chem Biol. 2012.

Modeling early bactericidal activity in murine tuberculosis provides insights into the activity of isoniazid and pyrazinamide. PNAS. 2012.

Mycobacterium tuberculosis Directs T Helper 2 Cell Differentiation by Inducing Interleukin-1β. J Biol Chem. 2012 Jul 18.

Isoniazid resistance without a loss of fitness in Mycobacterium tuberculosis. Nat Commun. 2012 Mar 20.

Mycobacterium tuberculosis WhiB4 regulates oxidative stress response. Mol Microbiol. 2012 Jul 11.

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K-RITH News

AECM Study Finds Vitamin C Can Kill Drug-Resistant TB

May 22, 2013

In an unexpected turn of events, researchers at Albert Einstein College of Medicine of Yeshiva University announced yesterday that they have determined that vitamin C kills drug-resistant tuberculosis (TB) bacteria in laboratory culture.

Students Hungry for Biostatistics

April 26, 2013

K-RITH’s second biostatistics course, hosted for the first time in the new K-RITH Tower Building, left students asking for more, and I don’t mean more of the Smarties and M&Ms that they were counting for their chi square test! No, it seems that the only thing that these students were hungry for was to learn more statistics!

VC of K-RITH's Founding Partner to receive Presidential Award

April 25, 2013

UKZN’s Vice-Chancellor and Principal, Professor Malegapuru Makgoba, and the Associate Scientific Director of Caprisa and renowned HIV/AIDS and TB researcher, Professor Quarraisha Abdool Karim, will receive national awards of commendation from President Jacob Zuma at the weekend.

Key Dates & Events

K-RITH Research Lecture Series: Daniel Kaufmann

June 14, 2013

Daniel Kaufmann, Assistant Professor at the Ragon Institute of MGH, MIT and Harvard will speak on 'Immunoregulation of HIV-specific CD4 T cell responses: a new therapeutic target?'

K-RITH Research Lecture Series: Hidde Ploegh

June 14, 2013

Hidde Ploegh, Professor of Immunopathology and Director of the Graduate Programme in Immunology, Harvard Medical School will speak on 'Biochemistry with a little help from our microbial friends'

K-RITH Speakers at the SAAIDS Conference

June 19, 2013 - June 21, 2013

K-RITH Director Dr. Bill Bishai will be speaking on “Advances in TB Treatment: Pummeling the Persisters” in plenary session 2 at the SAAIDS Conference on Wednesday 19 June. Click here to find out who else from K-RITH will be presenting at the conference.